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Zyvox (Linezolid) is an antibiotic which is used to manage severe bacterial infections that have not reacted to other antibiotics (resistant infections). It functions by preventing the expansion of bacteria. This antibiotic treats only bacterial infections.

Mechanism of action:
The mechanism of action for this drug is different than that of other antibacterial agents; therefore Jim Kelly Youth Jersey , cross-resistance between linezolid and other classes of antibiotics is unlikely. This product acts via inhibition of protein synthesis. It binds to a site on the bacterial 23S ribosomal RNA of the 50S subunit and prevents the formation of a functional 70S initiation complex. This step is essential for the bacterial translation process.

INDICATIONS AND USAGE

This drug is indicated for the treatment of infections caused by susceptible strains of the designated microorganisms in the specific conditions listed below.
Pneumonia
Nosocomial pneumonia caused by Staphylococcus aureus (methicillin-susceptible and -resistant isolates) or Streptococcus pneumoniae .
Community-acquired pneumonia caused by Streptococcus pneumoniae, including cases with concurrent bacteremia, or Staphylococcus aureus (methicillin-susceptible isolates only).

Skin and Skin Structure Infections
Complicated skin and skin structure infections, including diabetic foot infections, without concomitant osteomyelitis, caused byStaphylococcus aureus (methicillin-susceptible and -resistant isolates), Streptococcus pyogenes Nathan Peterman Youth Jersey , or Streptococcus agalactiae.
Uncomplicated skin and skin structure infections caused by Staphylococcus aureus (methicillin-susceptible isolates only) orStreptococcus pyogenes .
Vancomycin-resistant Enterococcus faecium Infections
Vancomycin-resistant Enterococcus faecium infections, including cases with concurrent bacteremia .

Usage
To reduce the development of drug-resistant bacteria and maintain the effectiveness of this medicine and other antibacterial drugs, this drug should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

CONTRAINDICATIONS
Hypersensitivity
This formulations are contraindicated for use in patients who have known hypersensitivity to linezolid or any of the other product components.
Monoamine Oxidase Inhibitors
This drug should not be used in patients taking any medicinal product which inhibits monoamine oxidases A or B (e.g. phenelzine, isocarboxazid) or within two weeks of taking any such medicinal product.

Drug interactions:
Some products that may interact with this drug include :
Atomoxetine, bethanidine Taron Johnson Youth Jersey , bupropion, carbamazepine, certain antihistamines (azatadine, carbetapentane, chlorpheniramine), certain eye drops (apraclonidine, brimonidine) Harrison Phillips Youth Jersey , herbal products (e.g., ephedrama huang, ginseng, tryptophan), indoramin, levodopa, methyldopa John Miller Youth Jersey , certain narcotic pain relievers (fentanyl, meperidine), papaverine, drugs for Parkinson's disease (such as entacapone, tolcapone), rifampin, sympathomimetics (e.g. Shaq Lawson Youth Jersey , ephedrine, methylphenidate), tetrabenazine, other drugs which depress the bone marrow (e.g., cancer chemotherapy).
Avoid taking other MAO inhibitors (isocarboxazid, methylene blue, moclobemide Dion Dawkins Youth Jersey , phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine) within 2 weeks before, during, and after treatment with this medication.

Side effects:
Painrednessswelling at the injection site may occur. Also Zay Jones Youth Jersey , diarrhea, headache, nausea, vomiting, dizziness, trouble sleeping, or constipation may occur.

Storage:
Store at 25 C (77 F); excursions permitted to 15 to 30 C (59 and 77 F). Store in a tight Tre'Davious White Youth Jersey , light-resistant container. Keep away from reach of children.

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10-31-2018, 03:34 AM
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